Author: Abhay Panchal

At the Paris AI Summit, U.S. Vice President J.D. Vance urged against overregulating AI, arguing that excessive caution could stifle innovation. This shift in perspective aligns with rapid advancements, including DeepSeek’s open-source AI models, which significantly reduce development costs and lower entry barriers for smaller companies. In healthcare, knowledge distillation—training AI on real-world patient interactions—is set to drive hyper-specialized AI applications. This could transform virtual care, improve chronic disease management, and reduce healthcare costs. AI-powered assistants trained on real patient data may soon provide scalable, affordable care, filling critical gaps without replacing human clinicians.

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Cylinder, a leading virtual digestive health provider, has appointed Ryan Sloan as its first Chief Commercial Officer (CCO) to oversee sales, health plan partnerships, and commercial strategy. With over 20 years of experience in healthcare, Sloan has held key roles at Galileo, Google’s Onduo, Aetna, and Vitality, specializing in digital health and value-based care.

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his World Obesity Day, the focus shifts from individuals to systemic factors shaping health, such as policy, healthcare systems, and social determinants like food security. A new commission in The Lancet Diabetes & Endocrinology calls for a shift away from BMI as the primary diagnostic tool for obesity, introducing ‘preclinical obesity’ and ‘clinical obesity’ to better classify disease progression. Similarly, experts argue that metabolic dysfunction-associated steatotic liver disease (MASLD) should be classified as a non-communicable disease (NCD) alongside cardiovascular disease, diabetes, cancer, and chronic respiratory disease. With MASLD affecting 30% of the global population, integrating it into public health strategies…

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On February 21, 2025, the FDA declared the semaglutide shortage resolved, stating that supply now meets or exceeds demand. This decision follows ongoing litigation with the Outsourcing Facilities Association (OFA), which filed a new lawsuit challenging the removal. The FDA has extended compounding allowances for state-licensed pharmacies until April 22, 2025, and outsourcing facilities until May 22, 2025. The legal battle over semaglutide’s availability may impact future compounding policies, especially as certain GLP-1 products continue to be compounded in various formulations.

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Scientists at Lawson Research Institute and London Health Sciences Centre Research Institute are pioneering a fecal microbiota transplantation (FMT) approach to improve chemotherapy response in advanced pancreatic cancer. The Phase I trial will use LND101 capsules, containing gut microbes from healthy donors, to modify tumor microbiomes and enhance immune function. Previous studies on melanoma, lung, and renal cancer suggest this treatment could improve survival rates, marking a potential breakthrough in cancer therapy.

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Sanford Health implemented an AI-driven risk model in its EHR to enhance colorectal cancer screening for 100,000 newly eligible patients following the USPSTF recommendation to begin screenings at age 45. The AI tool analyzes 85 nontraditional risk factors, increasing cancer detection rates fivefold compared to traditional models. It also prioritizes high-risk patients for colonoscopies and integrates at-home stool DNA tests to optimize screening backlogs. The next phase will expand the AI tool across all primary care clinics, with broader applications in early disease detection beyond colorectal cancer.

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A meta-analysis of five studies (10,833 patients) found that GLP-1 receptor agonist users were twice as likely to have inadequate bowel preparation for colonoscopy (10.6% vs. 4.6%; OR 2.10, P = 0.0003) and had lower Boston Bowel Preparation Scale (BBPS) scores. Researchers suggest gastrointestinal motility effects may contribute to poor prep adherence. The findings highlight the need for enhanced bowel prep strategies for these patients.

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A nationwide study from Japan found that the risk of colorectal cancer (CRC) varies among subgroups of steatotic liver disease (SLD), with the highest risk in patients with alcohol-associated liver disease (ALD) (1.73x higher), followed by MetALD (1.36x) and MASLD (1.28x). The study analyzed data from 6.38 million individuals and emphasizes the need for targeted CRC screening in high-risk SLD patients. Researchers suggest alcohol-related toxic metabolites, oxidative stress, and metabolic dysfunction contribute to these risk variations.

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