ACG Clinical Guideline: Treatment of Helicobacter pylori Infection (AJG)

Helicobacter pylori is a widespread infectious disease linked to dyspepsia, ulcers, and gastric cancer. The American College of Gastroenterology’s clinical practice guidelines recommend bismuth quadruple therapy (BQT) for 14 days as the first-line treatment, particularly when antibiotic resistance is unknown. Rifabutin triple therapy or potassium-competitive acid blocker dual therapy is suggested for patients without penicillin allergies. The guidelines also emphasize post-treatment testing for eradication, antibiotic susceptibility testing, and specific salvage treatments for persistent infections. Future research priorities are outlined to address gaps in current H. pylori management.