Can AI and Molecular Testing Outperform Colonoscopy? (The Pathologist)

Colonoscopy has long been the gold standard for colorectal cancer screening—but could AI and molecular testing change that? A new review explores how liquid biopsies, multi-omics, and AI-assisted colonoscopy are pushing the limits of early detection. While blood tests and stool assays promise convenience, their sensitivity lags behind. Meanwhile, cutting-edge tools like single-cell sequencing and spatial transcriptomics could rewrite how we diagnose and stratify risk. The big question: will these next-gen diagnostics ever truly rival colonoscopy’s dominance?