Key Points:
- A cohort study found that Agile scores based on vibration-controlled transient elastography (VCTE) accurately predicted liver-related events in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).
- Among over 16,000 patients, the incidence of liver-related events varied significantly based on baseline Agile scores. Higher Agile scores were associated with higher incidence rates of liver-related events.
- Agile scores showed higher overall accuracy in predicting liver-related events compared to other noninvasive tests, such as liver stiffness measurement (LSM) and various fibrosis scores.
- Serial Agile scores were stable over time in the majority of patients who underwent repeated VCTE, providing valuable insights for clinical management.
- The study suggests that VCTE-derived Agile scores could serve as a viable noninvasive alternative to liver biopsy for predicting the progression of MASLD, helping to identify patients at higher risk of adverse outcomes.