Registration delays likely led to ‘major underestimation’ of CRC risk reduction in NordICC (Healio)

The NordICC trial on colorectal cancer (CRC) screening might have underestimated 10-year risk reductions due to delays in cancer registration, affecting study outcomes. Researchers estimate that delays of up to 3 years could have reduced the accuracy of risk reduction by as much as 75%. While screening colonoscopy’s impact appears weaker than anticipated, experts urge caution in interpreting results until full 10- and 15-year follow-up data are available to assess true reductions in CRC risk and mortality.