GutGPT: A multidimensional knowledge-enhanced large language model for gastrointestinal medicine (ScienceDirect)

A landmark paper in the Journal of Biomedical Informatics presents GutGPT, the first large language model tailored exclusively for gastrointestinal medicine. Built on a foundation of nearly 200,000 curated entries—including real-world doctor–patient dialogues, clinical guidelines, medical knowledge graphs, and licensing exam data—GutGPT was fine-tuned using advanced techniques to balance efficiency, adaptability, and accuracy. In head-to-head comparisons with 16 existing models, it achieved state-of-the-art results, boosting diagnostic accuracy by nearly 10% and showing a marked improvement in empathetic communication with patients. Unlike general-purpose LLMs, GutGPT is designed to capture the complexity of GI diseases, which often require long-term management and patient self-education.