Colorectal cancer (CRC) stands as the second most common cause of cancer-related deaths worldwide. A concerning rise in early-onset colorectal cancer (EO-CRC), defined as diagnosis before the age of 50, has been observed globally over the past two decades. This form of CRC now accounts for about 10% of all CRC deaths. The article delves into the increasing incidence of EO-CRC and its potential causes, including Western dietary patterns, smoking, obesity, and changes in gut microbiota. The delay in diagnosis due to lack of awareness among both patients and providers is highlighted, emphasizing the importance of early recognition. Genetic factors, such as Lynch syndrome, are also discussed. The article concludes by stressing the need for increased awareness, continued research, and proactive interventions to combat the rising trend of EO-CRC.
Thought-Provoking Questions/Insights:
- Rising Incidence: With EO-CRC predicted to be the leading cause of cancer death in patients under 50 by 2030, what proactive measures can be implemented to curb this trend?
- Gut Microbiota’s Role: The gut microbiota is increasingly being recognized as a potential factor in EO-CRC. How might future research into gut health and microbiota influence prevention and treatment strategies?
- Awareness and Diagnosis: Given the challenges in early diagnosis due to lack of awareness, how can medical professionals and communities better educate the public about the risks and signs of EO-CRC?