The article discusses combination therapy in inflammatory bowel disease (IBD), aiming to improve patient outcomes by leveraging multiple therapeutic mechanisms. While traditional combination therapies (TCT) and advanced combination therapies (ACT) show promise, challenges such as limited long-term data and safety risks remain. Studies like SONIC and UC-SUCCESS highlight the benefits of combining biologics and immunomodulators. However, more research is needed to understand the full potential and risks of combination treatments, including insurance coverage and FDA approval challenges.
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