Cold Snare Resection Safe for Large Nonpedunculated Colorectal Polyps (MDedge)

The CHRONICLE trial from Germany suggests that cold snare endoscopic mucosal resection (EMR) may be safer than hot EMR for large colorectal polyps, with significantly fewer major adverse events. However, this comes with a trade-off: higher rates of polyp recurrence and residual adenoma. While cold EMR shows promise for certain polyp types, especially sessile serrated lesions, further research is needed to refine patient selection and techniques to reduce recurrence rates.