The use of 5-aminosalicylic acid significantly increases the risk for Clostridioides difficile infection in pediatric patients with inflammatory bowel disease, according to a new meta-analysis.
There is scant literature and conflicting findings on CDI risk factors in the pediatric IBD population according to the investigators. For example, antibiotic use in pediatric patients has shown mixed results. “Some studies reported that use of antibiotics was associated with higher CDI rates, while others showed that there was no effect,” they wrote.