Colorectal cancer (CRC) remains the second leading cause of cancer death in the U.S.—even as incidence and mortality have declined. Nearly 42% of adults aged 45–75 are not up to date with screening, missing opportunities to detect and prevent cancer early. While options like colonoscopy and stool-based tests are proven effective, participation lags due to discomfort, inconvenience, or stigma.
Current screening tools each have trade-offs, prompting the ongoing search for a test that is noninvasive, highly sensitive, specific, and broadly acceptable—the key to closing the persistent screening gap.