Author: Praveen Suthrum

CAMBRIDGE, Mass.–(BUSINESS WIRE)–Iterative Scopes, a pioneer in precision medicine technologies for gastroenterology, announced today that it has acquired Clinical Research Strategy Group, LLC and Precision Research (CRSG/Precision), two clinical trial optimization companies focused on streamlining and accelerating the drug development process for inflammatory bowel disease (IBD). The acquisitions deepen Iterative Scopes’ ties to the IBD clinical research community and strengthen its knowledge of the end-to-end research process with a focus on provider viewpoints and pain points.

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The Lexington, Massachusetts–based firm was founded quietly in 2015 and emerged in 2017 with $65 million in funding. It went public in 2019 and at the end of 2021 had 76 employees. But Kaleido disclosed in January that it had halted work on a drug in Phase 2 studies for chronic obstructive pulmonary disease and ended an agreement with the COPD Foundation.

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Klebsiella pneumoniae, which is found in higher concentrations in patients with inflammatory bowel disease, enhances the growth of Clostridioides difficile and worsens colonic inflammation in the presence of C. difficile infection, according to new research. “When C. difficile infection is superimposed on colitis, it synergistically worsens both conditions,” researcher Taylor Ticer, a PhD candidate at the Medical University of South Carolina, in Charleston, and colleagues reported at the 2022 Crohn’s and Colitis Congress (Inflamm Bowel Dis 2022;28[suppl 1]:S69)

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Las Vegas—Postmenopausal women on estrogen-containing hormone replacement therapy have a significantly increased risk for gastroesophageal reflux disease and Barrett’s esophagus, according to a population-based study. On multivariate analysis, the risks for GERD and Barrett’s esophagus were each more than sixfold greater in postmenopausal women who were taking HRT compared with those who were not (P<0.0001), according to an analysis led by Sherif Saleh, MD, an internal medicine resident at MetroHealth System, in Cleveland.

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