Las Vegas—Postmenopausal women on estrogen-containing hormone replacement therapy have a significantly increased risk for gastroesophageal reflux disease and Barrett’s esophagus, according to a population-based study.
On multivariate analysis, the risks for GERD and Barrett’s esophagus were each more than sixfold greater in postmenopausal women who were taking HRT compared with those who were not (P<0.0001), according to an analysis led by Sherif Saleh, MD, an internal medicine resident at MetroHealth System, in Cleveland.