As the 100th anniversary of Crohn’s disease approaches, the field of inflammatory bowel disease (IBD) has seen remarkable advancements, including biologics, small molecules, and personalized treatment strategies. These innovations have improved patient outcomes and quality of life, yet challenges persist, such as the increasing global incidence, financial burdens, and therapeutic limitations. This special issue of Clinical Gastroenterology and Hepatology brings together experts to review recent breakthroughs and explore future directions in IBD care, emphasizing the need for ongoing research and novel therapeutic approaches.
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