These Two Simple Interventions May Cut Colorectal Cancer Recurrence Risk (Medscape)

In a recent commentary, Dr. David Johnson highlights two accessible interventions—exercise and aspirin—that could significantly lower colorectal cancer recurrence risk.

The CHALLENGE trial found that adding just 45–60 minutes of brisk walking (or similar activity) three to four times a week after chemotherapy cut recurrence, new cancer, or death risk by 28% over nearly eight years.

Separately, the ALASCCA trial showed that for patients with PIK3CA-mutated colorectal cancer, daily low-dose aspirin reduced recurrence risk by nearly 50% at three years, with minimal side effects.