New treatments for stage 4 colorectal cancer are significantly improving outcomes. While the liver is the most common site of metastasis, therapies like hepatic artery infusion (HAI) deliver highly concentrated chemotherapy directly to the liver, reducing side effects and extending survival by up to 2 years. Additionally, liver transplants are now an option for select patients. Targeted therapies and immunotherapies, especially for those with genetic mutations like Lynch syndrome, are expanding hope.
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