Background
Coronavirus disease 2019 (COVID-19) is essentially a pulmonary disease due to SARS-CoV-2 infection of the respiratory tract. However, it can also proliferate in the intestinal tract. Of note, over 50% of COVID-19 patients exhibit SARS-CoV-2 shedding in their stools, indicated by the detection of SARS-CoV-2 in their feces. The SARS-CoV-2 Omicron and Delta strains replicate in the airways. However, the proliferation capabilities of the strains in intestinal organoids are unknown.