Artificial Intelligence (AI) is a type of intelligence that comes from machines or computer systems that mimics human cognitive function. Recently, AI has been utilized in medicine and helped clinicians make clinical decisions. In gastroenterology, AI has assisted colon polyp detection, optical biopsy, and diagnosis of Helicobacter pylori infection. AI also has a broad role in the clinical prediction and management of gastrointestinal bleeding. Machine learning can determine the clinical risk of upper and lower gastrointestinal bleeding. AI can assist the management of gastrointestinal bleeding by identifying high-risk patients who might need urgent endoscopic treatment or blood transfusion, determining bleeding stigmata during endoscopy, and predicting recurrence of gastrointestinal bleeding.