GLP-1 receptor agonists negatively impact colonoscopy bowel preparation, review finds (ACP Gastroenterology)

A meta-analysis of five studies (10,833 patients) found that GLP-1 receptor agonist users were twice as likely to have inadequate bowel preparation for colonoscopy (10.6% vs. 4.6%; OR 2.10, P = 0.0003) and had lower Boston Bowel Preparation Scale (BBPS) scores. Researchers suggest gastrointestinal motility effects may contribute to poor prep adherence. The findings highlight the need for enhanced bowel prep strategies for these patients.