Decoding the link between colorectal cancer risk and steatotic liver disease (Medical Xpress)

A nationwide study from Japan found that the risk of colorectal cancer (CRC) varies among subgroups of steatotic liver disease (SLD), with the highest risk in patients with alcohol-associated liver disease (ALD) (1.73x higher), followed by MetALD (1.36x) and MASLD (1.28x). The study analyzed data from 6.38 million individuals and emphasizes the need for targeted CRC screening in high-risk SLD patients. Researchers suggest alcohol-related toxic metabolites, oxidative stress, and metabolic dysfunction contribute to these risk variations.