New studies suggest that physical activity may decline rather than increase after starting GLP-1 medications, despite recommendations to exercise to help preserve lean mass. In a retrospective study of 753 GLP-1 users with wearable-tracker data, average daily steps fell from 5,047 to 4,487, while moderate-to-vigorous activity dropped from 27.9 to 22.2 minutes per day. A separate study found that 57.7% of GLP-1 users failed to meet the recommended 150 minutes of moderate-to-vigorous activity per week, with average sedentary time approaching 16 hours/day.
Weight Down, Steps Down: The GLP-1 Catch (Medscape)
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