A noninvasive magnetic neuromodulation therapy significantly improved fecal incontinence symptoms in a sham-controlled Phase 3 trial, with responder rates reaching 66% to 81% compared with 32% in the sham group after six weeks of treatment.
The therapy, called translumbosacral neuromodulation (TNT), uses external magnetic stimulation to target lumbosacral nerves involved in bowel control. Researchers also observed improvements in urgency, stool frequency, quality-of-life measures, anal squeeze pressures, and objective neurophysiologic markers, suggesting the treatment may address underlying neuropathy rather than simply masking symptoms.