A large U.S. real-world study of more than 326,000 average-risk adults found that repeat multitarget stool DNA (mt-sDNA) screening for colorectal cancer achieves consistently high adherence, exceeding 80% across all racial and ethnic groups. Overall repeat-testing adherence reached 86%, rising to more than 90% among patients with prior mt-sDNA experience.
Follow-up colonoscopy after a positive test occurred in 76% of cases — a critical step for effective screening. Older adults, rural residents, patients receiving digital outreach, and those whose tests were ordered by OB/GYNs were more likely to complete repeat screening.
The findings reinforce mt-sDNA as a scalable, home-based screening option with strong real-world adherence and meaningful follow-through.