First Real-World Evidence of an AI-Enhanced Digital Collaborative Care Model to Improve IBS Symptoms (WILEY)

A first-of-its-kind real-world study reports that an AI-enhanced digital collaborative care model (Ayble Health) delivered big, durable gains for people with IBS—without requiring a brick-and-mortar “IBS clinic.” In a prospective single-arm cohort of 202 adults with active symptoms, participants chose among three pathways—personalized elimination diet, brain–gut behavioral therapy (GDH/CBT/ACT), and a care team with coach support—while AI mined multimodal data to flag patterns and suggest next steps. Average symptom burden (IBS-SSS) fell by 140 points, and 86% achieved a clinically meaningful ≥50-point drop, with improvements emerging by week 4 and persisting out to 42 weeks; benefits were seen across IBS subtypes and were greatest when patients used multiple pathways.