In a groundbreaking study, Microsoft’s new AI tool, the Medical AI Diagnostic Orchestrator (MAI-DxO), correctly diagnosed 85% of complex medical cases from The New England Journal of Medicine — four times better than human doctors, who scored just 20%. The AI also did so 20% more cost-effectively.
Unlike previous static models, MAI-DxO mimics the way doctors iteratively gather data, order tests, and reason through diagnoses — even emulating real-world consultations through an “orchestrator” system of multiple AI models like GPT, Claude, and Gemini. The project was advised by Dr. Eric Topol, a renowned physician-scientist, who called the findings “startling,” particularly the combination of superior accuracy and lower cost.
Still in research stages, MAI-DxO may redefine global access to expert-level diagnostics, especially in underserved areas — if it proves itself in real-world clinical trials.