Neurogastroenterology is a subspecialty of gastroenterology that overlaps with neurology. The enteric nervous system is a collection of neurones that can function independently of the central nervous system (CNS). This article discusses the neurologic manifestations of gastroenterological disorders as well as significant gastroenterological manifestations of neurologic disorders. The CNS plays a role in the pathogenesis of some gastrointestinal disorders. Management depends on the individual disorder. Some general approaches to treatment of various gastrointestinal manifestations of neurologic disease are outlined in this article. Among the specialized procedures in development, transplantation of neural stem cells is a promising therapeutic approach for disorders of the enteric nervous system.