The tumor necrosis factor (TNF) inhibitor infliximab (Remicade) was associated with attenuated serological responses to SARS-CoV-2 infection in patients with inflammatory bowel disease (IBD), a multicenter study from the U.K. found.
These responses were further attenuated in those who also received immunomodulators, said Tariq Ahmad, MD, of the Royal Devon and Exeter NHS Foundation Trust in England, and colleagues.
Compared with vedolizumab (Entyvio), infliximab was independently tied to lower seropositivity (OR 0.66, 95% CI 0.51-0.87, P=0.0027), as was concomitant immunomodulator use (OR 0.70, 95% CI 0.53-0.92, P=0.012), they reported online in Gut.