In his latest Ground Truths essay, Eric Topol unpacks a wave of breakthroughs placing the gut-brain axis at the heart of modern medicine. From gut-derived T cells triggering neuroinflammation to H. pylori proteins blocking amyloid plaques, the gut is no longer just about digestion—it’s influencing immunity, neurodegeneration, and metabolic health.
Topol also spotlights a surge in next-gen GLP-1s—oral, injectable, even triple agonists—being studied for everything from obesity and diabetes to sleep apnea and Alzheimer’s. The future of brain and immune health, he argues, may be driven not by the brain itself, but by what we feed and foster in our gut.