Drugs which are commonly-used as the first line of treatment for colorectal cancer cause the tumor cells to oversecrete mucins, according to a new study (“Reversing chemorefraction in colorectal cancer cells by controlling mucin secretion”) published in eLife. The proteins alter the mucous layer, forming a physical barrier that prevents drugs from reaching their intended target.
Tackling Colorectal Cancer Drug Resistance by Reversing Chemorefraction
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