Key Blood Proteins Predict MASLD Up to 16 Years in Advance (Medscape)

A landmark study presented at DDW 2025 has identified five blood proteins—CDHR2, FUOM, KRT18, ACY1, and GGT1—that can predict the development of metabolic dysfunction-associated steatotic liver disease (MASLD) up to 16 years before symptoms appear. The predictive model, derived from over 52,000 participants in the UK Biobank, demonstrated up to 90.4% accuracy at five years and 82.2% at 16 years, outperforming all existing models. Researchers suggest this ultra-early detection could revolutionize liver disease prevention through personalized interventions long before liver damage begins.