A study published in March 2025 in Cancer Epidemiology, Biomarkers & Prevention offers important insights for the future of colorectal cancer (CRC) screening, particularly in how the cost-effectiveness of new noninvasive tests could reshape current practices. Here’s an overview of the research.The Study’s Design.
Using a simulated model of 100,000 average-risk 45-year-old adults, the research compared three novel screening options—multitarget stool RNA (mt-sRNA), multitarget stool DNA 2.0, and cell-free DNA tests—against guideline-recommended methods like colonoscopy, fecal immunochemical testing, and stool DNA testing.