Key Points:
- Computer-aided detection (CADe) in colonoscopy has not shown improvement in adenoma detection rates (ADR) in real-world, nonrandomized trials, contradicting positive findings from randomized trials.
- CADe-assisted colonoscopy has been gaining attention for its potential to improve ADR, especially following a meta-analysis involving 20 randomized controlled trials (RCTs).
- Real-world results cast doubt on the generalizability of RCT findings. RCTs are susceptible to validity issues like psychological bias and the possibility of reducing operator attention.
- A new meta-analysis analyzed nonrandomized data from eight studies involving 9,782 patients, revealing less favorable outcomes than RCTs.