Colorectal cancer (CRC) remains a leading cause of cancer-related deaths, with several screening recommendations to enhance early detection. Despite differing guidelines, most recommend beginning screening at age 45 or 50 based on risk factors. Colonoscopy is the gold standard for CRC screening, but stool-based tests like FIT and gFOBT are valuable, especially for lower-risk individuals. Recent advancements include blood-based assays like the SEPT9 DNA test and ctDNA-based Shield™ blood test, alongside stool-based options like Cologuard Plus. These alternatives aim to increase screening accessibility and compliance. The ACP’s updated guidelines also stress quality measures in colonoscopy, highlighting critical techniques to improve detection rates and reduce missed lesions.
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