Two types of bariatric-metabolic surgery were more effective than lifestyle modification plus best medical care in the treatment of non-alcoholic steatohepatitis (NASH), a randomized trial from Italy showed.
In over 200 patients with obesity and biopsy-confirmed NASH who completed the study, the primary endpoint of histological resolution of NASH (without worsening of fibrosis) was met by 56% of patients assigned to Roux-en-Y and 57% of those randomized to sleeve gastrectomy, as compared with only 16% of participants who underwent lifestyle modification, reported Geltrude Mingrone, MD, PhD, of King’s College London, and colleagues.