Proteins, often perceived as static 3D structures, can change their shapes based on biological needs, acting like biological transistors. While AI has previously been used to predict and even generate novel protein structures, a new study in Science has introduced flexibility to these AI-designed proteins. These proteins can stabilize into two distinct forms, similar to a hinge being open or closed, based on an external biological “lock.” Dr. Florian Praetorius from the University of Washington highlighted the potential applications of these dynamic proteins. The proteins were designed using a combination of AI tools, including AlphaFold and Rosetta. The ultimate goal…
Author: Abhay Panchal
Colorectal cancer (CRC) stands as the second most common cause of cancer-related deaths worldwide. A concerning rise in early-onset colorectal cancer (EO-CRC), defined as diagnosis before the age of 50, has been observed globally over the past two decades. This form of CRC now accounts for about 10% of all CRC deaths. The article delves into the increasing incidence of EO-CRC and its potential causes, including Western dietary patterns, smoking, obesity, and changes in gut microbiota. The delay in diagnosis due to lack of awareness among both patients and providers is highlighted, emphasizing the importance of early recognition. Genetic factors,…
The Core Quality Measures Collaborative (CQMC) has unveiled new core quality measures along with implementation guidelines for specific core sets. These measures, shaped by over 75 healthcare entities, span 10 specialties, with eight of them undergoing updates. The updates encompass patient outcomes measures, evaluating care coordination and transitions quality. Some measures were removed either because they were no longer evidence-based or didn’t significantly boost performance. These alterations will influence clinicians aiming to enhance care quality and might also impact CMS recommendations. Michelle Schreiber from CMS and Danielle A. Lloyd from AHIP emphasized the importance of alignment across federal, state, and…
Vial, a tech-driven CRO focused on next-generation clinical trial management, has announced a strategic partnership with Documenso, an open-source digital signing platform. This collaboration aims to revolutionize document signing practices in the life sciences sector, offering an alternative to traditional platforms like DocuSign. The partnership will focus on meeting the stringent requirements of CFR Part 11 compliance, a set of FDA guidelines for electronic recordkeeping and signatures in regulated sectors. Simon Burns, CEO of Vial, emphasized the partnership’s potential to innovate document management in the life sciences, aligning with the demands of 21 CFR Part 11. On the other hand,…
Ambulatory Surgery Center (ASC) leaders are currently observing several significant trends in the industry. One of the primary shifts is the migration of procedures from inpatient to outpatient settings, driven by advancements in surgical techniques and technology. This change offers a more cost-effective and convenient option for patients but requires ASCs to continually upgrade their facilities and skills. Another trend is the adoption of value-based care, focusing on patient outcomes and cost-effectiveness rather than the traditional fee-for-service model. ASCs are participating more in bundled payment programs and other value-based initiatives, emphasizing quality improvement and data collection to demonstrate value and…
InDex Pharmaceuticals Holding AB announced that the positive results from their pharmacokinetic (PK) study with cobitolimod, targeting patients with moderate to severe ulcerative colitis, will be showcased at the United European Gastroenterology Week (UEGW). This abstract was distinguished as one of the best for poster presentation and will also be orally presented in a moderated session. Jenny Sundqvist, CEO of InDex Pharmaceuticals, expressed her satisfaction with the selection, emphasizing the medical community’s keen interest in their findings. The study’s results, presented by Professor Per Hellström, revealed limited systemic uptake of cobitolimod and a promising response rate among patients. InDex Pharmaceuticals…
Patients who have ulcerative colitis and Crohn’s disease often report symptoms without showing endoscopic evidence of the disease, and their providers struggle to make sense of the disparity. In a new study, investigators used fecal calprotectin levels to assess symptoms most associated with disease activity. “A patient will say they’re having lots and lots of symptoms, but we don’t find inflammation during a colonoscopy, which means we need to investigate other causes,” said Kerri Glassner, DO, an assistant professor of clinical medicine at Houston Methodist Hospital and Weill Cornell Medical College, in New York City, who was not involved in…
CHICAGO—While artificial intelligence is increasingly seen as a means of improving endoscopy, studies at Digestive Disease Week 2023 hinted at a potential flaw: It may not be as effective outside of the controlled environment of randomized trials, that is, in routine community practice. “We did not see an increase in adenoma detection rate [ADR] with CADe [computer-aided detection] over baseline and saw no improvement in any performance tertile,” reported investigator Uri Ladabaum, MD, who presented results of one large study in the community setting. “There was also no significant difference between the outcomes of endoscopists in the CADe study sites…
Jamie M. Horrigan, MD, a chief resident in internal medicine at Dartmouth Health’s Dartmouth Hitchcock Medical Center (DHMC), has been honored by the Crohn’s & Colitis Foundation New England Chapter as the 2023 Rising Community Leader in IBD. The recognition was given during the foundation’s annual “Stories from the Gut” event. Dr. Horrigan, who herself has Crohn’s, was nominated for her advocacy efforts, particularly her Instagram account and blog, “Sweetened by Nature,” where she shares insights to assist those with IBD. Through her advocacy, she successfully fundraised $8,000 for the foundation, surpassing her initial goal of $5,000. Dr. Corey A.…
Gastro Health, GI Alliance and PE GI Solutions, One GI and United Digestive are five of the largest private equity-backed gastroenterology groups in the industry. Here’s a breakdown of some of the must-know gastroenterology front-runners: Affiliated physicians: