A randomized trial published in Lancet Gastroenterology & Hepatology found that appendectomy, when added to standard medical therapy, significantly reduced relapse rates in ulcerative colitis (UC) patients in remission compared to medical therapy alone. At 1 year, only 36% of patients in the appendectomy group relapsed, versus 56% in the control group. The surgery group also showed less need for biologics, better quality of life, and lower disease activity scores.
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