The U.S. Multi-Society Task Force on Colorectal Cancer has published a new review and consensus statement on serrated polyposis syndrome (SPS), emphasizing that the condition is frequently underrecognized despite being associated with increased colorectal cancer risk. The task force recommends using the 2019 WHO criteria for diagnosis and systematically documenting the number, size and location of serrated polyps when multiple lesions are identified. Pasted text
For patients with SPS, the recommendations favor endoscopic management over surgery when there is no concurrent CRC. Colonoscopy should be performed by endoscopists with a documented sessile serrated lesion detection rate of at least 6%, using high-definition white-light colonoscopy with or without chromoendoscopy. The task force recommends a 3–6-month clearance phase followed by surveillance every 1–2 years, with selected patients having substantially reduced polyp burdens potentially considered for 3-year intervals. Pasted text
The statement also recommends cold-snare resection for sessile serrated lesions and hyperplastic polyps in SPS patients, while individuals whose polyp burden cannot be managed endoscopically should be referred to an advanced endoscopist before surgical resection.