The gut-skin axis (GSA) is emerging as a key player in linking gastrointestinal health to dermatological diseases through immune, metabolic, and microbial pathways. This narrative review highlights how dysbiosis, leaky gut, and systemic inflammation can manifest as skin disorders like acne, psoriasis, atopic dermatitis, and hidradenitis suppurativa — often serving as early warning signs of underlying GI disease.
For gastroenterologists, the GSA offers both a diagnostic lens and a therapeutic opportunity. Microbiome-targeted interventions — probiotics, prebiotics, dietary strategies, and even fecal microbiota transplantation — show promise in reshaping systemic inflammation and improving outcomes in both gut and skin conditions.